Cleaved-Caspase-3 p12 (D175) Polyclonal Antibody

CASP3 encodes caspase 3 which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 3 cleaves and activates caspases 6, 7 and 9, and caspase 3 itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of CASP3 results in two transcript variants that encode the same protein.

The Cleaved-Caspase-3 p12 (D175) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of cleaved caspase-3 p12 protein in various biological samples. This antibody is produced using advanced techniques, ensuring high affinity and specificity towards the target protein.

Caspase-3 is a crucial enzyme involved in the execution phase of apoptosis, playing a pivotal role in cell death regulation. The cleaved form of caspase-3, known as caspase-3 p12, is a reliable marker for apoptotic cell death. By targeting the D175 region of the cleaved caspase-3 p12 protein, this polyclonal antibody enables accurate identification and measurement of apoptotic events.

The Cleaved-Caspase-3 p12 (D175) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It demonstrates minimal cross-reactivity with other proteins, ensuring reliable and specific results. This antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and cultured cells.

With its high sensitivity and specificity, the Cleaved-Caspase-3 p12 (D175) Polyclonal Antibody is an indispensable tool for researchers and scientists studying apoptosis and cell death pathways. Its reliable performance and accurate detection capabilities make it an ideal choice for both basic research and clinical applications.

We guarantee the quality and performance of our Cleaved-Caspase-3 p12 (D175) Polyclonal Antibody, backed by rigorous quality control measures. Each batch is thoroughly tested to ensure consistent and reliable results. Our dedicated technical support team is available to assist you with any inquiries or troubleshooting.

Choose the Cleaved-Caspase-3 p12 (D175) Polyclonal Antibody for precise and reliable detection of cleaved caspase-3 p12 protein, and unlock new insights into apoptotic processes.