Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody

CASP2 (caspase 2) encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of CASP2 may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for CASP2.

The Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Cleaved-Caspase-2 p18 protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

Caspase-2 is a crucial enzyme involved in the initiation and execution of apoptosis, a programmed cell death process. Cleaved-Caspase-2 p18 is the active form of Caspase-2, which is generated upon proteolytic cleavage at threonine 325. The detection and measurement of Cleaved-Caspase-2 p18 protein levels are of great significance in understanding the apoptotic pathway and its dysregulation in various diseases, including cancer.

The Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody exhibits high affinity and specificity towards Cleaved-Caspase-2 p18 protein, enabling accurate and precise detection. It has been extensively validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. This antibody demonstrates minimal cross-reactivity with other related proteins, ensuring reliable and specific results.

Furthermore, the Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody is produced using state-of-the-art production techniques, ensuring batch-to-batch consistency and high purity. It is supplied as a liquid formulation, ready for immediate use, eliminating the need for time-consuming reconstitution steps.

In summary, the Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of Cleaved-Caspase-2 p18 protein. Its exceptional performance, sensitivity, and specificity make it an invaluable asset for researchers and scientists studying apoptosis and its implications in various diseases.