Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody

CASP2 encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. Caspase 2 may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of CASP2 may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

The Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection of cleaved caspase-2 p18 (G170) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the cleaved caspase-2 p18 (G170) protein sequence. The resulting polyclonal antibody is purified using protein A affinity chromatography and validated for specificity and sensitivity using various techniques, including Western blotting, immunohistochemistry, and immunofluorescence.

The Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody is suitable for use in a wide range of applications, including research studies investigating the role of caspase-2 in apoptosis and other cellular processes. This antibody is highly specific for the cleaved caspase-2 p18 (G170) protein and does not cross-react with other caspase family members or unrelated proteins. Additionally, this antibody exhibits high sensitivity, allowing for the detection of low levels of cleaved caspase-2 p18 (G170) protein in complex biological samples.

In summary, the Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody is a reliable and effective tool for the detection of cleaved caspase-2 p18 (G170) protein in various biological samples. Its high specificity and sensitivity make it an ideal choice for researchers investigating the role of caspase-2 in apoptosis and other cellular processes.