CLC-4 Polyclonal Antibody

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. CLCN4 is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.

The Claudin-3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Claudin-3 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

Claudin-3 is a key component of tight junctions, playing a crucial role in maintaining the integrity and barrier function of epithelial and endothelial cell layers. Dysregulation of Claudin-3 expression has been implicated in various pathological conditions, including cancer progression and metastasis.

The Claudin-3 Polyclonal Antibody exhibits exceptional specificity, binding exclusively to Claudin-3 protein without cross-reactivity to other Claudin family members. It has been extensively validated in multiple experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody demonstrates superior sensitivity, enabling the detection of low levels of Claudin-3 protein expression. Its robust performance ensures reliable and accurate results, making it an ideal choice for both basic research and clinical applications.

The Claudin-3 Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is available in various sizes to accommodate different experimental requirements.

With its exceptional specificity, sensitivity, and reliability, the Claudin-3 Polyclonal Antibody is an indispensable tool for researchers and clinicians studying the role of Claudin-3 in various physiological and pathological processes.