Claudin-4 Polyclonal Antibody

Claudin 4 encoded by this intronless gene (CLDN4) belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

The Claudin-4 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Claudin-4 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Claudin-4 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Claudin-4 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in detecting Claudin-4 protein in various tissues and cell lines. It has been shown to recognize a single band of the expected molecular weight in Western blotting and to produce strong and specific staining in immunohistochemistry and immunofluorescence assays.

This antibody is an essential tool for researchers studying the role of Claudin-4 protein in various physiological and pathological processes, including cancer, inflammation, and infectious diseases. Its high specificity and sensitivity make it an ideal reagent for the detection and quantification of Claudin-4 protein in various biological samples.

In summary, the Claudin-4 Polyclonal Antibody is a reliable and high-quality antibody that is suitable for use in various applications. Its specificity and sensitivity make it an essential tool for researchers studying the role of Claudin-4 protein in various biological processes.