Claudin-4 Polyclonal Antibody

Claudin 4 encoded by this intronless gene (CLDN4) belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

The Claudin-4 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Claudin-4 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

Claudin-4 is a key component of tight junctions, playing a crucial role in maintaining the integrity and barrier function of epithelial and endothelial cell layers. Dysregulation of Claudin-4 expression has been implicated in various pathological conditions, including cancer, inflammation, and infectious diseases. Therefore, the accurate detection and quantification of Claudin-4 expression is of utmost importance in both research and clinical settings.

The Claudin-4 Polyclonal Antibody exhibits exceptional specificity, binding exclusively to the target protein without cross-reactivity to other Claudin family members. This antibody has been extensively validated in various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence, ensuring reliable and reproducible results.

With its high sensitivity, this antibody allows for the detection of low levels of Claudin-4 expression, enabling researchers to study subtle changes in protein expression levels. Its versatility and compatibility with multiple sample types, including cell lysates, tissue sections, and cultured cells, make it an ideal choice for a wide range of applications.

The Claudin-4 Polyclonal Antibody is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming and complex antibody preparation procedures. It is provided in a liquid formulation, ensuring ease of use and minimizing the risk of sample contamination.

In summary, the Claudin-4 Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of Claudin-4 protein expression. Its high specificity, sensitivity, and versatility make it an invaluable asset for researchers and clinicians alike, facilitating advancements in the understanding and treatment of various diseases.