Claudin-3 Polyclonal Antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The claudin 3 encoded by CLDN3, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.

The Claudin-7 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Claudin-7 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards Claudin-7.

Claudin-7 is a crucial component of tight junctions, playing a vital role in maintaining the integrity and barrier function of epithelial and endothelial cell layers. Dysregulation of Claudin-7 expression has been implicated in various pathological conditions, including cancer progression and metastasis.

The Claudin-7 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its reliability and accuracy in detecting Claudin-7 expression in both normal and diseased tissues.

With its high sensitivity and specificity, this antibody enables researchers to gain valuable insights into the role of Claudin-7 in various biological processes and disease mechanisms. Its robust performance and consistent results make it an indispensable tool for scientists and clinicians involved in studying tight junctions, epithelial biology, and cancer research.

The Claudin-7 Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and minimizing experimental variability. It is available in various sizes to accommodate different experimental needs. Each batch of antibody undergoes rigorous quality control procedures to ensure optimal performance and reproducibility.

In summary, the Claudin-7 Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of Claudin-7 protein expression. Its high specificity, sensitivity, and versatility make it an invaluable asset for researchers and clinicians working in the field of tight junction biology and cancer research.