Claudin-3 Polyclonal Antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The claudin 3 encoded by CLDN3, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.

The Claudin-3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Claudin-3 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

Claudin-3 is a key component of tight junctions, playing a crucial role in maintaining the integrity and barrier function of epithelial and endothelial cell layers. Dysregulation of Claudin-3 expression has been implicated in various pathological conditions, including cancer progression and metastasis.

The Claudin-3 Polyclonal Antibody exhibits exceptional specificity, binding exclusively to Claudin-3 protein without cross-reactivity to other Claudin family members. It has been extensively validated in multiple experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody demonstrates superior sensitivity, enabling the detection of low levels of Claudin-3 protein expression. Its robust performance ensures reliable and accurate results, making it an ideal choice for both basic research and clinical applications.

The Claudin-3 Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is available in various sizes to accommodate different experimental requirements.

With its exceptional specificity, sensitivity, and reliability, the Claudin-3 Polyclonal Antibody is an indispensable tool for researchers and clinicians studying the role of Claudin-3 in various physiological and pathological processes.