Claudin-11 Polyclonal Antibody

CLDN11 encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by CLDN11 is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein claudin 11 is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.

The Claudin-11 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Claudin-11 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Claudin-11 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and validated for its specificity and sensitivity through various assays.

The Claudin-11 protein is a member of the Claudin family of proteins, which are integral membrane proteins that form tight junctions between cells. Claudin-11 is primarily expressed in the testis and plays a crucial role in the formation and maintenance of the blood-testis barrier. Dysregulation of Claudin-11 expression has been implicated in various diseases, including male infertility and testicular cancer.

The Claudin-11 Polyclonal Antibody is an essential tool for researchers studying the function and regulation of Claudin-11 protein in various biological processes and diseases. This antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It is available in various sizes and formats to meet the specific needs of different research projects.

In summary, the Claudin-11 Polyclonal Antibody is a high-quality and reliable antibody that provides accurate and sensitive detection of Claudin-11 protein in various biological samples. Its specificity and sensitivity make it an essential tool for researchers studying the role of Claudin-11 in various biological processes and diseases.