Claudin-1 Polyclonal Antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by CLDN1, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

The Claudin-1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Claudin-1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Claudin-1 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Claudin-1 Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples and has been shown to exhibit high specificity and sensitivity in detecting Claudin-1 protein.

This antibody is an essential tool for researchers studying the role of Claudin-1 in various physiological and pathological processes, including cancer, inflammation, and infectious diseases. Its high specificity and sensitivity make it an ideal choice for detecting Claudin-1 protein in complex biological samples.

In summary, the Claudin-1 Polyclonal Antibody is a reliable and effective tool for the detection of Claudin-1 protein in various biological samples. Its high specificity and sensitivity make it an essential tool for researchers studying the role of Claudin-1 in various physiological and pathological processes.