Chk2 Polyclonal Antibody

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. Checkpoint kinase 2 encoded by CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in CHEK2 have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in CHEK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for CHEK2.

The CHSY2 Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced using high-quality polyclonal antibodies that have been purified and validated to ensure optimal performance. The CHSY2 Polyclonal Antibody is specifically designed to target the CHSY2 protein, which is involved in the biosynthesis of chondroitin sulfate, a major component of the extracellular matrix. This antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. The CHSY2 Polyclonal Antibody is a reliable and effective tool for researchers studying the role of chondroitin sulfate in various biological processes. With its high specificity and sensitivity, this antibody is an essential tool for any researcher working in the field of extracellular matrix biology.