ChemR23 Polyclonal Antibody

The C-X3-C chemokine family is characterized by two cysteines separated by three amino acid residues. Fractalkine is a member of this chemokine family that binds CX3CR1, previously named V28, and chemokine b receptor-like 1 (CMKBRL1) with high affinity, to induce either leukocyte adhesion and migration or chemotactic functions. CX3CR1 functions with CD4 as a co-receptor for the HIV-1 virus envelope protein, and patients homozygous for a variant haplotype of CX3CR1 progress to AIDS more rapidly than those with other haplotypes. Chemokine receptor-like 1 (also designated G protein-coupled receptor DEZ or ChemR23) belongs to the G protein-coupled receptor 1 family. It is an integral membrane protein functioning as a receptor, possibly a chem-otactic peptide receptor. It also acts as a coreceptor for various SIV strains and for a primary HIV-1 strain. ChemR23 is highly expressed in developing osseous and cartilaginous tissue, brain, kidney, gastrointestinal tissues and myeloid tissue, as well as in adult parathyroid glands.

The ChemR23 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of ChemR23 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human ChemR23 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards ChemR23 protein, making it an ideal tool for various research applications.

The ChemR23 Polyclonal Antibody has been extensively validated for its performance in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been shown to detect ChemR23 protein in a wide range of species, including human, mouse, and rat. The antibody is supplied as a purified IgG fraction, which has been affinity-purified using Protein A chromatography to ensure high purity and specificity.

This antibody is an essential tool for researchers studying the role of ChemR23 protein in various physiological and pathological processes, including inflammation, immune response, and cancer. Its high sensitivity and specificity make it an ideal reagent for the detection and quantification of ChemR23 protein in complex biological samples, such as serum, plasma, and tissue lysates.

In summary, the ChemR23 Polyclonal Antibody is a highly specific and sensitive immunological reagent that is essential for researchers studying the role of ChemR23 protein in various biological processes. Its high affinity and specificity make it an ideal tool for various research applications, including Western blotting, immunohistochemistry, and ELISA.