Cerebellin 2 Polyclonal Antibody

Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. CER and it metabolite des-Ser1-cerebellin are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other's degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of CER has been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for CER in the pathology of these diseases.

The Cerebellin 2 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Cerebellin 2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminus of human Cerebellin 2 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards Cerebellin 2 protein, making it an ideal tool for various research applications.

The Cerebellin 2 Polyclonal Antibody has been extensively validated for use in Western blotting, immunohistochemistry, and immunofluorescence assays. It has been shown to detect endogenous levels of Cerebellin 2 protein in human, mouse, and rat tissues, including brain, spinal cord, and cerebellum. This antibody has also been used successfully in various studies investigating the role of Cerebellin 2 in synaptic plasticity, motor coordination, and neurodegenerative diseases.

The Cerebellin 2 Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified using a Cerebellin 2 peptide column. It is provided in a liquid format, ready for use in various applications. This antibody is highly specific and sensitive, with minimal cross-reactivity to other proteins, ensuring reliable and reproducible results.

In summary, the Cerebellin 2 Polyclonal Antibody is a high-quality research tool that offers exceptional sensitivity and specificity for the detection of Cerebellin 2 protein in various biological samples. Its versatility and reliability make it an ideal choice for researchers investigating the role of Cerebellin 2 in various physiological and pathological processes.