CEP135 Polyclonal Antibody

CEP135 (centrosomal protein 135) encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in CEP135 are associated with autosomal recessive primary microcephaly-8.

The Cdc16 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Cdc16 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Cdc16 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and is suitable for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Cdc16 protein is a key component of the anaphase-promoting complex/cyclosome (APC/C), which is a large multi-subunit E3 ubiquitin ligase that plays a critical role in regulating the cell cycle. Specifically, Cdc16 is involved in the activation of the APC/C during mitosis, which leads to the degradation of key cell cycle regulators and the progression of the cell cycle. Dysregulation of the APC/C has been implicated in a variety of human diseases, including cancer, making the Cdc16 Polyclonal Antibody a valuable tool for researchers studying the molecular mechanisms underlying these diseases.

Overall, the Cdc16 Polyclonal Antibody is a high-quality research reagent that offers excellent sensitivity and specificity for the detection of Cdc16 protein in a variety of biological samples. Its use in a range of applications makes it a versatile tool for researchers studying the cell cycle and related processes.