CENP-A Polyclonal Antibody

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

The CENP-A Polyclonal Antibody is a highly specific and sensitive tool for the detection of centromere protein A (CENP-A) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CENP-A protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CENP-A, making it an ideal reagent for various applications, including immunoblotting, immunoprecipitation, and immunofluorescence.

The CENP-A Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested for its performance in various experimental conditions. This antibody is supplied as a purified IgG fraction, and is suitable for use in both research and diagnostic applications.

With its high specificity and sensitivity, the CENP-A Polyclonal Antibody is an essential tool for researchers studying the role of CENP-A in various cellular processes, including chromosome segregation, mitosis, and cell division. Its reliable performance and consistent results make it a valuable addition to any laboratory working in the field of cell biology and molecular biology.