CD74 Polyclonal Antibody

CD74 molecule encoded by CD74 associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

The CD74 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of CD74 protein expression in various biological samples. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reproducibility.

CD74, also known as the major histocompatibility complex (MHC) class II-associated invariant chain, plays a crucial role in antigen presentation and immune response regulation. It is expressed on the surface of antigen-presenting cells, such as dendritic cells, macrophages, and B cells. CD74 is involved in the trafficking and loading of MHC class II molecules with antigenic peptides, thereby facilitating their presentation to T cells.

The CD74 Polyclonal Antibody exhibits high affinity and specificity towards CD74 protein, enabling accurate detection and quantification in various experimental applications, including Western blotting, immunohistochemistry, and flow cytometry. It recognizes both the full-length CD74 protein and its cleaved forms, allowing for comprehensive analysis of CD74 expression and processing.

This antibody is produced using purified recombinant CD74 protein as an immunogen, ensuring high specificity and minimal cross-reactivity with other proteins. It has been extensively validated in multiple cell lines and tissues, demonstrating consistent and reliable results. The CD74 Polyclonal Antibody exhibits excellent sensitivity, enabling detection of low levels of CD74 expression, making it suitable for a wide range of research applications.

With its exceptional performance characteristics and reliable results, the CD74 Polyclonal Antibody is an indispensable tool for researchers studying antigen presentation, immune response regulation, and related fields. Its high specificity, sensitivity, and versatility make it an ideal choice for both basic research and clinical applications.