CD72 Polyclonal Antibody

CD5 has been identified as a transmembrane glycoprotein that is expressed on 70% of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/CD3 ζ chain, and with the Src family kinase, Lck p56. The C-type lectin superfamily member CD72 is a cell surface negative regulator of B cell activation from the pro-B through the mature B cell stage. CD72 serves as a receptor for CD5. The ability of lymphocytes to respond to antigenic or mitogenic stimulation utilizes both positive and negative regulatory proteins that influence the threshold for responsiveness. The human CD72 gene maps to chromosome 9p13.3 and encodes a transmembrane glycoprotein that contains an immunoreceptor tyrosine-based inhibition motif (ITIM). Upon tyrosine phosphorylation, the CD72 ITIM recruits SH2-containing phosphatases such as SHP-1, resulting in downregulation of cell activation. CD72-/- mice contain hyperproliferative B cells.

The CD72 Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and analysis of CD72 protein expression in various biological samples. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The CD72 Polyclonal Antibody exhibits exceptional affinity and specificity towards CD72, a cell surface glycoprotein that plays a crucial role in regulating B cell activation and signaling. This antibody recognizes the extracellular domain of CD72 and has been validated for use in various applications, including Western blotting, immunohistochemistry, and flow cytometry.

With its superior sensitivity and specificity, the CD72 Polyclonal Antibody enables accurate and precise detection of CD72 protein expression levels in both normal and diseased tissues. Its versatility allows for a wide range of experimental applications, making it an invaluable tool for researchers studying B cell biology, immunology, and related fields.

The CD72 Polyclonal Antibody is supplied as a liquid formulation in a convenient size, ensuring ease of use and storage. It is recommended to store this antibody at -20°C to maintain its stability and activity. Each batch of the CD72 Polyclonal Antibody undergoes rigorous quality control testing to ensure consistent performance and reliability.

In summary, the CD72 Polyclonal Antibody is a highly specific and sensitive immunological tool that enables accurate detection and analysis of CD72 protein expression. Its exceptional affinity and versatility make it an essential component for researchers in the field of B cell biology and immunology.