CD71 Polyclonal Antibody

CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. CD71 binds to two molecules of transferrin and a serum iron-transport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticulocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregulated upon activation of lymphocytes, monocytes and macrophages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.

The CD71 Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of CD71 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and consistency in every batch.

The CD71 Polyclonal Antibody exhibits exceptional affinity and specificity towards CD71, also known as transferrin receptor protein 1 (TfR1). It recognizes the extracellular domain of CD71, which is involved in the cellular uptake of iron-bound transferrin. This antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and flow cytometry.

With its superior sensitivity, the CD71 Polyclonal Antibody enables accurate and reliable detection of CD71 expression levels, even in low abundance samples. Its broad reactivity across multiple species, including human, mouse, and rat, makes it a versatile tool for diverse research applications.

The CD71 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimizing wastage. Each vial is quality-controlled to meet the highest standards of performance, ensuring consistent and reproducible results.

In summary, the CD71 Polyclonal Antibody is a valuable tool for researchers studying CD71 protein expression and its role in various biological processes. Its exceptional sensitivity, specificity, and versatility make it an indispensable asset in the field of immunology and molecular biology.