CD55 Polyclonal Antibody

CD55 encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins.

The CD55 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CD55 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CD55 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CD55 protein, making it an ideal tool for various research applications.

The CD55 protein, also known as decay-accelerating factor (DAF), is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a critical role in regulating the complement system. It functions by inhibiting the formation of the C3 and C5 convertases, which are key enzymes in the complement cascade. Dysregulation of CD55 expression or function has been implicated in various pathological conditions, including autoimmune diseases, infectious diseases, and cancer.

The CD55 Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and flow cytometry. It has been validated for use in human, mouse, and rat samples, and exhibits minimal cross-reactivity with other related proteins. This antibody is supplied as a purified IgG fraction, and is available in various sizes to meet the needs of different research applications.

In summary, the CD55 Polyclonal Antibody is a highly specific and sensitive immunological reagent that enables the detection and quantification of CD55 protein in various biological samples. Its high affinity and specificity make it an ideal tool for various research applications, including the study of complement system regulation, autoimmune diseases, infectious diseases, and cancer.