CD42b Polyclonal Antibody

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]GP1BA (Glycoprotein Ib Platelet Alpha Subunit) is a Protein Coding gene. Diseases associated with GP1BA include von willebrand disease, platelet-type and bernard-soulier syndrome, type a2. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include thrombin receptor activity. GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.\

The CD44 Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and analysis of CD44 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and consistency in every batch.

CD44 is a cell surface glycoprotein that plays a crucial role in cell adhesion, migration, and signaling. It is involved in numerous physiological and pathological processes, including embryogenesis, inflammation, and cancer metastasis. The CD44 Polyclonal Antibody recognizes the extracellular domain of CD44, allowing for the precise identification and characterization of CD44-positive cells.

This antibody has been extensively validated in various experimental settings, including Western blotting, immunohistochemistry, and flow cytometry. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of CD44 expression levels. The CD44 Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue sections, and cultured cells.

With its superior performance and versatility, the CD44 Polyclonal Antibody is an indispensable tool for researchers and clinicians studying CD44 biology and its implications in disease progression. Its robust and reproducible results make it an ideal choice for both basic research and clinical applications.

To ensure optimal performance, the CD44 Polyclonal Antibody should be stored at -20°C upon arrival. It is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming preparation. Each vial contains sufficient antibody for multiple experiments, providing excellent value for money.

In summary, the CD44 Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of CD44 protein expression. Its high specificity, sensitivity, and versatility make it an essential component of any research or diagnostic laboratory.