CD30-L Polyclonal Antibody

The tumor necrosis factor superfamily member 8 encoded by TNFSF8 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.

The CD30-L Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of CD30-L protein expression. This antibody is produced through a rigorous and meticulous process, ensuring its high affinity and specificity towards CD30-L.

CD30-L, also known as CD153, is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily. It is primarily expressed on activated T cells, B cells, and dendritic cells. CD30-L plays a crucial role in immune regulation, particularly in T cell-dependent B cell activation and differentiation. Dysregulation of CD30-L expression has been implicated in various pathological conditions, including autoimmune diseases and cancer.

The CD30-L Polyclonal Antibody is validated for multiple applications, including Western blotting, immunohistochemistry, and flow cytometry. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of CD30-L protein expression in various sample types.

This antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The CD30-L Polyclonal Antibody is compatible with a wide range of experimental conditions and can be used in both research and clinical settings.

With its exceptional performance and reliability, the CD30-L Polyclonal Antibody is an indispensable tool for researchers and clinicians studying CD30-L biology and its implications in disease. Its high specificity and sensitivity make it an ideal choice for accurate and precise quantification of CD30-L protein expression, facilitating a deeper understanding of its role in immune regulation and disease pathogenesis.