CD209 Polyclonal Antibody

CD209 encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The CD209 molecule is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

The CD209 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CD209 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CD209 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CD209 protein, making it an ideal tool for various research applications.

The CD209 Polyclonal Antibody is suitable for use in a variety of immunoassays, including Western blotting, immunohistochemistry, and flow cytometry. It has been validated for use in human, mouse, and rat samples, and has been shown to exhibit minimal cross-reactivity with other proteins. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The CD209 Polyclonal Antibody is a valuable tool for researchers studying the role of CD209 protein in various biological processes, including immune response, infection, and inflammation. Its high specificity and sensitivity make it an ideal reagent for the detection and quantification of CD209 protein in complex biological samples. With its reliable performance and ease of use, the CD209 Polyclonal Antibody is an essential tool for any laboratory conducting research in this field.