CD158z Polyclonal Antibody

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13. within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008]KIR3DL3 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3) is a Protein Coding gene. Among its related pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. An important paralog of this gene is KIR2DL4. Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.

The CD158z Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of CD158z protein in various biological samples. This antibody is produced using high-quality polyclonal antibodies that have been purified and validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and flow cytometry.

The CD158z protein is a member of the killer cell immunoglobulin-like receptor (KIR) family, which plays a crucial role in regulating the activity of natural killer (NK) cells. The CD158z protein is expressed on the surface of NK cells and is involved in the recognition and killing of target cells, particularly those infected with viruses or cancer cells.

The CD158z Polyclonal Antibody is a valuable tool for researchers studying the function and regulation of NK cells in various physiological and pathological conditions. It is highly specific and sensitive, allowing for accurate and reliable detection of CD158z protein in various biological samples. Its versatility and ease of use make it an ideal choice for a wide range of research applications.

In summary, the CD158z Polyclonal Antibody is a high-quality, reliable, and versatile antibody that is essential for researchers studying the function and regulation of NK cells. Its specificity and sensitivity make it an ideal tool for a wide range of research applications, and its ease of use makes it a valuable addition to any laboratory.