CD158f2 Polyclonal Antibody

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13. within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

The CD158f2 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CD158f2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CD158f2 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CD158f2 protein, making it an ideal tool for various research applications.

The CD158f2 Polyclonal Antibody is suitable for use in a variety of immunoassays, including Western blotting, immunohistochemistry, and flow cytometry. It has been validated for use in human samples and has been shown to detect CD158f2 protein in a variety of tissues and cell types. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The CD158f2 Polyclonal Antibody is a valuable tool for researchers studying the role of CD158f2 protein in various biological processes, including immune response, inflammation, and cancer. Its high specificity and sensitivity make it an ideal reagent for the detection and quantification of CD158f2 protein in complex biological samples. With its reliable performance and consistent results, the CD158f2 Polyclonal Antibody is a must-have for any laboratory conducting research in this field.