CD13 Polyclonal Antibody

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.

The CD13 Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of CD13 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and consistency in every batch.

CD13, also known as aminopeptidase N, is a membrane-bound metalloprotease that plays a crucial role in various physiological and pathological processes. It is widely expressed in various cell types, including leukocytes, endothelial cells, and epithelial cells. CD13 has been implicated in immune regulation, angiogenesis, tumor invasion, and viral entry.

The CD13 Polyclonal Antibody exhibits exceptional specificity, binding exclusively to the CD13 antigen without cross-reactivity to other related proteins. It recognizes both the native and denatured forms of CD13, making it suitable for a wide range of applications, including Western blotting, immunohistochemistry, flow cytometry, and immunofluorescence.

This antibody demonstrates high sensitivity, enabling the detection of low levels of CD13 expression in samples with limited protein content. It exhibits a low background signal, ensuring accurate and reliable results. The CD13 Polyclonal Antibody is validated for use in various species, including human, mouse, and rat, making it a versatile tool for researchers in diverse fields.

With its exceptional performance characteristics and broad applicability, the CD13 Polyclonal Antibody is an indispensable tool for studying CD13 protein expression and its functional implications in various biological processes. It offers researchers a reliable and reproducible means to investigate the role of CD13 in health and disease, paving the way for advancements in biomedical research and potential therapeutic interventions.