CBP (Acetyl Lys1535) Polyclonal Antibody

CREBBP is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), CREBBP is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREB binding protein has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. CREB binding protein acetylates both histone and non-histone proteins. CREB binding protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in CREBBP cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving CREBBP have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

The CBP (Acetyl Lys1535) Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of the CBP protein. This antibody is produced using high-quality polyclonal antibodies that have been raised against the acetylated lysine residue at position 1535 of the CBP protein. The antibody has been extensively validated for use in a variety of applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The CBP protein is a transcriptional co-activator that plays a critical role in the regulation of gene expression. It is involved in a wide range of cellular processes, including cell growth, differentiation, and apoptosis. The acetylation of lysine residues on the CBP protein is an important post-translational modification that regulates its activity and function.

The CBP (Acetyl Lys1535) Polyclonal Antibody is an essential tool for researchers studying the CBP protein and its role in cellular processes. Its high specificity and sensitivity make it ideal for detecting even low levels of the acetylated CBP protein in complex biological samples. The antibody is supplied in a convenient format and is ready to use in a variety of applications.

In summary, the CBP (Acetyl Lys1535) Polyclonal Antibody is a high-quality antibody that is essential for researchers studying the CBP protein and its role in cellular processes. Its high specificity and sensitivity make it an ideal tool for detecting the acetylated CBP protein in complex biological samples.