Cbl Polyclonal Antibody

CBL is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein (Cbl proto-oncogene) is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. CBL has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in CBL are also the cause of Noonan syndrome-like disorder.

The Cbl Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Cbl protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity. With its exceptional performance, this antibody enables accurate and precise identification of Cbl protein in Western blotting, immunohistochemistry, and immunofluorescence applications.

The Cbl Polyclonal Antibody exhibits excellent specificity, exhibiting minimal cross-reactivity with other proteins, thus ensuring reliable and accurate results. Its robust and consistent performance guarantees reproducibility, making it an ideal choice for both research and diagnostic purposes.

This antibody is supplied in a ready-to-use format, allowing for convenient and efficient experimentation. Its long shelf life and stability ensure consistent performance over time, minimizing the need for frequent reordering.

The Cbl Polyclonal Antibody is an indispensable tool for researchers and clinicians alike, facilitating the investigation of Cbl protein function and its involvement in various cellular processes. Its exceptional quality and performance make it an essential component of any laboratory or diagnostic setting.