Cbl Polyclonal Antibody

CBL is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein (Cbl proto-oncogene) is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. CBL has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in CBL are also the cause of Noonan syndrome-like disorder.

The Cbl Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Cbl protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminus of human Cbl protein. The resulting polyclonal antibody exhibits high affinity and specificity towards Cbl protein, making it an ideal tool for various applications in research and diagnostics.

The Cbl Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunoprecipitation, and immunohistochemistry. It has been validated for use in human, mouse, and rat samples, and has been shown to detect both full-length and truncated forms of Cbl protein. This antibody is supplied as a purified IgG fraction, and has been tested for its specificity and sensitivity in various applications.

The Cbl Polyclonal Antibody is a valuable tool for researchers and clinicians studying the role of Cbl protein in various physiological and pathological processes. Its high specificity and sensitivity make it an ideal reagent for the detection and quantification of Cbl protein in various biological samples, including tissues, cells, and body fluids. With its reliable performance and consistent results, the Cbl Polyclonal Antibody is a must-have reagent for any laboratory working in the field of molecular biology and biomedicine.