Cbl Polyclonal Antibody

CBL is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein (Cbl proto-oncogene) is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. CBL has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in CBL are also the cause of Noonan syndrome-like disorder.

The Cathepsin D Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Cathepsin D protein in various biological samples. This antibody is produced using advanced techniques, ensuring high affinity and specificity towards Cathepsin D.

Cathepsin D is a lysosomal protease that plays a crucial role in the degradation of intracellular proteins. It is involved in various physiological and pathological processes, including cell proliferation, apoptosis, and tumor progression. The Cathepsin D Polyclonal Antibody enables researchers to investigate the expression and localization of Cathepsin D in different tissues and cell types.

This antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

The Cathepsin D Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering.

With its exceptional sensitivity and specificity, the Cathepsin D Polyclonal Antibody is an indispensable tool for researchers studying the role of Cathepsin D in various biological processes. Its reliable performance and ease of use make it an ideal choice for both basic research and clinical applications.