Caspase-7 Polyclonal Antibody

CASP7 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of caspase 7 is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

The Caspase-7 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Caspase-7 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Caspase-7 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Caspase-7 Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples and has been shown to exhibit minimal cross-reactivity with other caspase family members.

This antibody is an essential tool for researchers studying apoptosis and cell death pathways. It enables the detection and quantification of Caspase-7 protein levels in various biological samples, providing valuable insights into the mechanisms of cell death and disease progression. The Caspase-7 Polyclonal Antibody is a reliable and high-quality reagent that is backed by rigorous quality control testing and is guaranteed to perform consistently in a wide range of applications.