Caspase-4 Polyclonal Antibody

CASP4 (caspase 4) encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, caspase 4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

The Caspase-4 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Caspase-4 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Caspase-4 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Caspase-4 Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples and has been shown to exhibit minimal cross-reactivity with other caspase family members.

This antibody is an essential tool for researchers studying the role of Caspase-4 in various cellular processes, including apoptosis, inflammation, and immune response. Its high specificity and sensitivity make it an ideal choice for detecting Caspase-4 protein levels in various biological samples.

In summary, the Caspase-4 Polyclonal Antibody is a reliable and effective tool for the detection of Caspase-4 protein in various biological samples. Its high specificity and sensitivity make it an essential tool for researchers studying the role of Caspase-4 in various cellular processes.