Caspase-2 Polyclonal Antibody

CASP2 encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein (caspase 2) may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of CASP2 may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for CASP2.

The Caspase-2 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Caspase-2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Caspase-2 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Caspase-2 Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples and has been shown to exhibit minimal cross-reactivity with other caspase family members.

This antibody is an essential tool for researchers studying the role of Caspase-2 in various cellular processes, including apoptosis, cell cycle regulation, and DNA damage response. Its high specificity and sensitivity make it an ideal choice for detecting Caspase-2 protein levels in complex biological samples.

In summary, the Caspase-2 Polyclonal Antibody is a reliable and effective tool for the detection of Caspase-2 protein in various biological samples. Its high specificity and sensitivity make it an essential tool for researchers studying the role of Caspase-2 in various cellular processes.