Casein Kinase IGamma2 Polyclonal Antibody

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.

The Caspase-1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Caspase-1 protein in various biological samples. This antibody has been rigorously tested and validated to ensure its reliability and accuracy in experimental settings.

Caspase-1, also known as interleukin-1 beta converting enzyme (ICE), is a crucial enzyme involved in the inflammatory response and programmed cell death. It plays a pivotal role in the activation and maturation of pro-inflammatory cytokines, such as interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). Dysregulation of Caspase-1 activity has been implicated in various pathological conditions, including autoimmune diseases, neurodegenerative disorders, and cancer.

The Caspase-1 Polyclonal Antibody has been developed using high-quality immunogens and advanced immunization techniques. It exhibits exceptional specificity towards Caspase-1, with minimal cross-reactivity to other related caspases. This antibody recognizes both the pro-form and the active form of Caspase-1, enabling comprehensive analysis of its expression and activation status.

This antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. It has been optimized for use in various species, including human, mouse, and rat, ensuring its versatility and applicability in diverse research fields.

The Caspase-1 Polyclonal Antibody offers researchers a reliable and robust tool for investigating the role of Caspase-1 in cellular processes and disease pathogenesis. Its high sensitivity and specificity make it an ideal choice for both qualitative and quantitative analysis of Caspase-1 protein levels. With its exceptional performance and consistent results, this antibody is an indispensable asset for any laboratory conducting research in the field of caspase biology and related disciplines.

Note: This product is for research use only and is not intended for diagnostic or therapeutic purposes.