Calretinin Polyclonal Antibody

CALB2 (calbindin 2) encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants.

The Calretinin Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of calretinin protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human calretinin protein. The resulting polyclonal antibody exhibits high affinity and specificity towards calretinin protein, making it an ideal tool for various research applications.

The Calretinin Polyclonal Antibody is suitable for use in a variety of techniques, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for use in human, mouse, and rat samples, and has been shown to exhibit minimal cross-reactivity with other proteins. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Calretinin Polyclonal Antibody is an essential tool for researchers studying the role of calretinin protein in various physiological and pathological processes. It can be used to investigate the expression and localization of calretinin in different tissues and cell types, as well as to explore its potential as a diagnostic and prognostic marker for various diseases. With its high sensitivity and specificity, this antibody is a valuable addition to any laboratory conducting research in the field of neuroscience, cancer biology, and developmental biology.