Cadherin-7 Polyclonal Antibody

CDH7 encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in CDH7 may be associated with bipolar disease in human patients. CDH7 is present in a gene cluster on chromosome 18.

The Cadherin-7 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Cadherin-7 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity towards Cadherin-7.

Cadherin-7, also known as CDH7, is a calcium-dependent cell adhesion molecule that plays a crucial role in cell-cell adhesion and tissue morphogenesis. It is primarily expressed in neural tissues, including the brain and spinal cord, as well as in certain epithelial tissues. Dysregulation of Cadherin-7 expression has been implicated in various pathological conditions, such as cancer metastasis and neurodevelopmental disorders.

The Cadherin-7 Polyclonal Antibody has been extensively validated for its specificity and performance in various experimental applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other cadherin family members, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without compromising its quality. The Cadherin-7 Polyclonal Antibody is manufactured under strict quality control standards, ensuring batch-to-batch consistency and reproducibility.

In summary, the Cadherin-7 Polyclonal Antibody is a valuable tool for researchers studying Cadherin-7 protein expression and its functional implications. Its high specificity, sensitivity, and versatility make it an ideal choice for a wide range of applications in both basic and clinical research.