BRCA2 Polyclonal Antibody

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

The BRCA2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of BRCA2 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

The BRCA2 gene is known to play a crucial role in DNA repair and maintenance of genomic stability. Mutations in this gene have been associated with an increased risk of developing breast and ovarian cancers. Therefore, the accurate detection and quantification of BRCA2 protein expression is of utmost importance in cancer research and diagnostics.

The BRCA2 Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes both native and denatured forms of the BRCA2 protein, allowing for comprehensive analysis of its expression levels and subcellular localization.

This antibody has been extensively validated using a wide range of cell lines and tissue samples, ensuring reliable and reproducible results. It demonstrates minimal cross-reactivity with other proteins, guaranteeing specific detection of BRCA2.

With its superior sensitivity and specificity, the BRCA2 Polyclonal Antibody is an indispensable tool for researchers and clinicians involved in cancer biology, genetics, and personalized medicine. Its reliable performance and versatility make it an ideal choice for studying BRCA2 protein expression and its implications in cancer development and treatment.