Acetyl p53 (K319) Polyclonal Antibody

TP53 (tumor protein p53) encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons.

The Acetyl p53 (K319) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated p53 protein at lysine 319 residue. This antibody is produced through a rigorous process of immunization using a synthetic peptide corresponding to the acetylated p53 (K319) region, followed by purification to ensure high affinity and specificity.

The Acetyl p53 (K319) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It recognizes acetylated p53 (K319) with remarkable sensitivity, enabling accurate quantification and localization of this modified protein in complex biological samples.

This antibody is manufactured under stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It has been extensively validated using a wide range of cell lines and tissues, demonstrating its reliability and robustness in detecting acetylated p53 (K319) across diverse experimental conditions.

The Acetyl p53 (K319) Polyclonal Antibody is an indispensable tool for researchers studying the role of p53 acetylation in various cellular processes, including DNA damage response, cell cycle regulation, and apoptosis. Its high specificity and sensitivity make it an ideal choice for investigating the functional significance of p53 acetylation in disease development and therapeutic interventions.

We offer this antibody in various sizes to accommodate different experimental needs. Each vial is carefully packaged and shipped with detailed instructions for optimal handling and storage. Our dedicated technical support team is available to provide expert guidance and assistance to ensure successful implementation of this antibody in your research.

Choose the Acetyl p53 (K319) Polyclonal Antibody for reliable and accurate detection of acetylated p53 (K319) and advance your understanding of p53-mediated cellular processes.