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ELK Biotechnology
SKU:ES11978
RGRF1 Rabbit Polyclonal Antibody
RGRF1 Rabbit Polyclonal Antibody
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$248.00 USD
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RGRF1 Rabbit Polyclonal Antibody
Overview
| Product name: | RGRF1 rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from part region of human protein |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 140kD |
| GeneID（Human）: | 5923 |
| Human Swiss-Prot No: | Q13972 |
| Cellular localization: | intracellular,cytosol,plasma membrane,growth cone,neuron projection, |
| Background: | The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009], |
| Species Reactivity: | Human;Mouse;Rat |
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