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ELK Biotechnology
SKU:ES11928
ZBT7A Rabbit Polyclonal Antibody
ZBT7A Rabbit Polyclonal Antibody
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$248.00 USD
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ZBT7A Rabbit Polyclonal Antibody
Overview
| Product name: | ZBT7A rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from part region of human protein |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 64kD |
| GeneID（Human）: | 51341 |
| Human Swiss-Prot No: | O95365 |
| Cellular localization: | Nucleus . Recruited to double-strand break sites of damaged DNA. . |
| Background: | function:Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 4 C2H2-type zinc fingers.,subunit:Interacts with BCL6.,tissue specificity:Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level)., |
| Species Reactivity: | Human;Mouse;Rat |
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