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ELK Biotechnology
SKU:ES11925
PHLP1 Rabbit Polyclonal Antibody
PHLP1 Rabbit Polyclonal Antibody
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$248.00 USD
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PHLP1 Rabbit Polyclonal Antibody
Overview
| Product name: | PHLP1 rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from part region of human protein |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 188kD |
| GeneID（Human）: | 23239 |
| Human Swiss-Prot No: | O60346 |
| Cellular localization: | Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. In colorectal cancer tissue, expression is concentrated at the lateral membrane of epithelial cells.; [Isoform 2]: Cell membrane . |
| Background: | PH domain and leucine rich repeat protein phosphatase 1(PHLPP1) Homo sapiens This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011], |
| Species Reactivity: | Human;Mouse;Rat |
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