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ELK Biotechnology
SKU:ES11434
SARM1 Rabbit Polyclonal Antibody
SARM1 Rabbit Polyclonal Antibody
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$248.00 USD
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SARM1 Rabbit Polyclonal Antibody
Overview
| Product name: | SARM1 rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from human protein . at AA range: 281-330 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 79kD |
| GeneID（Human）: | 23098 |
| Human Swiss-Prot No: | Q6SZW1 |
| Cellular localization: | Cytoplasm . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse . Mitochondrion . Associated with microtubules. . |
| Background: | caution:Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.,function:Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.,similarity:Contains 1 TIR domain.,similarity:Contains 2 SAM (sterile alpha motif) domains.,subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.,tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta., |
| Species Reactivity: | Human;Mouse |
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