1 1

ELK Biotechnology

ES11410

JPH2 Rabbit Polyclonal Antibody

JPH2 Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
Sale Sold out
Shipping calculated at checkout.
Size

JPH2 Rabbit Polyclonal Antibody

Overview

Product name: JPH2 rabbit pAb
Applications: WB;ELISA
Recommended Dilutions: WB 1:500-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human protein . at AA range: 611-660
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 76kD
GeneID（Human）: 57158
Human Swiss-Prot No: Q9BR39
Cellular localization: [Junctophilin-2]: Cell membrane ; Peripheral membrane protein . Sarcoplasmic reticulum membrane ; Single-pass type IV membrane protein . Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands. .; [Junctophilin-2 N-terminal fragment]: Nucleus . Accumulates in the nucleus of stressed hearts. .
Background: Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Rat;Mouse;
View full details