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ELK Biotechnology
SKU:ES11020
KLOTB Rabbit Polyclonal Antibody
KLOTB Rabbit Polyclonal Antibody
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$248.00 USD
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KLOTB Rabbit Polyclonal Antibody
Overview
| Product name: | KLOTB rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from part region of human protein |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 114kD |
| GeneID（Human）: | 152831 |
| Human Swiss-Prot No: | Q86Z14 |
| Cellular localization: | Cell membrane ; Single-pass type III membrane protein . |
| Background: | domain:Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 889. These domains are therefore predicted to be inactive.,function:Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.,similarity:Belongs to the glycosyl hydrolase 1 family.,similarity:Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.,subunit:Interacts with FGFR1 and FGFR4., |
| Species Reactivity: | Human;Mouse |
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