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ELK Biotechnology
SKU:ES10871
UVRAG Rabbit Polyclonal Antibody
UVRAG Rabbit Polyclonal Antibody
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$248.00 USD
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UVRAG Rabbit Polyclonal Antibody
Overview
| Product name: | UVRAG rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from part region of human protein. AA range 655-675 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 76kD |
| GeneID（Human）: | 7405 |
| Human Swiss-Prot No: | Q9P2Y5 |
| Cellular localization: | Late endosome . Lysosome . Cytoplasmic vesicle, autophagosome . Early endosome . Endoplasmic reticulum . Midbody . Chromosome, centromere . Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial (PubMed:24056303). Recruited to autophagosome following interaction with RUBCNL/PACER (PubMed:28306502). . |
| Background: | This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Rat;Mouse; |
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