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ELK Biotechnology
SKU:ES10786
P3C2B Rabbit Polyclonal Antibody
P3C2B Rabbit Polyclonal Antibody
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P3C2B Rabbit Polyclonal Antibody
Overview
| Product name: | P3C2B rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from part region of human protein |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 179kD |
| GeneID（Human）: | 5287 |
| Human Swiss-Prot No: | O00750 |
| Cellular localization: | Microsome . Cell membrane . Cytoplasm, cytosol . Nucleus . Endoplasmic reticulum . Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis. |
| Background: | The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Rat;Mouse; |
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