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ELK Biotechnology
SKU:ES10700
I12R2 Rabbit Polyclonal Antibody
I12R2 Rabbit Polyclonal Antibody
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$248.00 USD
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I12R2 Rabbit Polyclonal Antibody
Overview
| Product name: | I12R2 rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from human protein . at AA range: 270-350 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 94kD |
| GeneID（Human）: | 3595 |
| Human Swiss-Prot No: | Q99665 |
| Cellular localization: | Membrane; Single-pass type I membrane protein. |
| Background: | interleukin 12 receptor subunit beta 2(IL12RB2) Homo sapiens The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012], |
| Species Reactivity: | Human;Mouse |
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