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ELK Biotechnology
SKU:ES10598
KAISO Rabbit Polyclonal Antibody
KAISO Rabbit Polyclonal Antibody
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$248.00 USD
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KAISO Rabbit Polyclonal Antibody
Overview
| Product name: | KAISO rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from human protein . at AA range: 100-180 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 73kD |
| GeneID（Human）: | 10009 |
| Human Swiss-Prot No: | Q86T24 |
| Cellular localization: | Nucleus . Cytoplasm . Also cytoplasmic in cells grown at high densities. |
| Background: | This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear impor |
| Species Reactivity: | Human;Mouse |
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