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ELK Biotechnology
SKU:ES10566
TAB3 Rabbit Polyclonal Antibody
TAB3 Rabbit Polyclonal Antibody
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$248.00 USD
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TAB3 Rabbit Polyclonal Antibody
Overview
| Product name: | TAB3 rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from part region of human protein |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 78kD |
| GeneID（Human）: | 257397 |
| Human Swiss-Prot No: | Q8N5C8 |
| Cellular localization: | nucleoplasm,cytoplasm,cytosol,plasma membrane,endosome membrane,extracellular exosome, |
| Background: | The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Mouse |
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