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ELK Biotechnology
SKU:ES10142
PTPRK Rabbit Polyclonal Antibody
PTPRK Rabbit Polyclonal Antibody
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$248.00 USD
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PTPRK Rabbit Polyclonal Antibody
Overview
| Product name: | PTPRK rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from human protein . at AA range: 180-260 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 158kD |
| GeneID（Human）: | 5796 |
| Human Swiss-Prot No: | Q15262 |
| Cellular localization: | Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. |
| Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Mouse |
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