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ELK Biotechnology
SKU:ES9099
IBTK Rabbit Polyclonal Antibody
IBTK Rabbit Polyclonal Antibody
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$248.00 USD
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IBTK Rabbit Polyclonal Antibody
Overview
| Product name: | IBTK rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from human protein . at AA range: 410-490 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 148kD |
| GeneID（Human）: | 25998 |
| Human Swiss-Prot No: | Q9P2D0 |
| Cellular localization: | Cytoplasm. Membrane; Peripheral membrane protein. Translocates to the plasma membrane upon IgM stimulation.; [Isoform 2]: Nucleus. |
| Background: | Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014], |
| Species Reactivity: | Human;Rat;Mouse; |
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